Isolated Compounds and Cardiotonic Effect on the Isolated Rabbit Heart of Methanolic Flower Extract of Nerium oleander L.

Title:	Isolated Compounds and Cardiotonic Effect on the Isolated Rabbit Heart of Methanolic Flower Extract of Nerium oleander L.
Authors:	Vu, Duc Loi Bui, Thanh Tung
Keywords:	Nerium oleanderL;Cardiac glycoside;Flavonoids;Isolated rabbit heart;Cardiotonic effect
Issue Date:	2016

URI:	http://repository.vnu.edu.vn/handle/VNU_123/11501

Nerium oleander L. is an evergreen shrub in the dogbane family Apocynaceae and planted throughout the tropical region. It has cardiotonic, antioxidant, anti-inflammatory and anticancer activities.Nerium oleanderL. has high amount of cardiac glycoside and flavonoids compounds. From methanol extract of flowers of Nerium oleanderL. grown in vietnam, it has been isolated four compounds. Their structures were identified as (1) D 16 -Dehydroadynerigenin, (2) D 16 -Digitoxigenin, (3) Quercetin and (4) Kaempferol on the basis of spectroscopic data and by comparing their physicochemical and spectral data with those published studies. The effect of fraction HF2, which containing compound 1 and 2 on heart function was examined, revealing potent positive inotropic effect on isolated rabbit heart by increasing the contractility and coronary flow heart but does not alter heart rate